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DIABLO predesign siRNASynthetic RNA
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| RI11506 | 5 OD 400 ul | 13-15 days | $ 110.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
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DIABLO predesign siRNA - Additional info | |
| Gene ID | 56616 |
| Gene Symbol | DIABLO |
| Other Names SMAC, SMAC3, DIABLO-S, FLJ10537, FLJ25049, DIABLO | |
| Format HPLC purified siRNA is supplied as a dried pellet in nmol quantities. | |
| Storage Maintain refrigerated at 2-8°C for up to one week. For long term storage store at -20°C. | |
| Precautions This product is for research use only. Not for use in diagnostic or therapeutic procedures. | |
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BACKGROUND
This gene encodes an inhibitor of apoptosis protein (IAP)-binding protein. The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis, and it moderates the caspase inhibition of IAPs. Multiple polyadenylation sites have been found for this gene. Four alternatively spliced transcript variants have been described for this gene, with two of them encoding different isoforms and the other two probably not encoding a protein.
REFERENCES
Overexpression of Smac/DIABLO in Hep-2 cell line: possible role in potentiating the sensitivity of chemotherapeutic drugs. Lu S, et al. Tumori, 2010 Mar-Apr. PMID 20572591. Hip2 interacts with and destabilizes Smac/DIABLO. Bae Y, et al. Biochem Biophys Res Commun, 2010 Jul 9. PMID 20537984. Survivin and Smac gene expressions but not livin are predictors of prognosis in non-small cell lung cancer patients treated with adjuvant chemotherapy following surgery. Dai CH, et al. Jpn J Clin Oncol, 2010 Apr. PMID 20056675. Role for X-linked Inhibitor of apoptosis protein upstream of mitochondrial permeabilization. Owens TW, et al. J Biol Chem, 2010 Jan 8. PMID 19875445. Defining the human deubiquitinating enzyme interaction landscape. Sowa ME, et al. Cell, 2009 Jul 23. PMID 19615732.
