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DUSP6 predesign siRNASynthetic RNA
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| RI11635 | 5 OD 400 ul | 13-15 days | $ 110.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
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- Backgrounds
DUSP6 predesign siRNA - Additional info | |
| Gene ID | 1848 |
| Gene Symbol | DUSP6 |
| Other Names MKP3, PYST1, DUSP6 | |
| Format HPLC purified siRNA is supplied as a dried pellet in nmol quantities. | |
| Storage Maintain refrigerated at 2-8°C for up to one week. For long term storage store at -20°C. | |
| Precautions This product is for research use only. Not for use in diagnostic or therapeutic procedures. | |
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Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Two transcript variants encoding different isoforms have been found for this gene.
REFERENCES
Dual specificity phosphatase 6 (DUSP6) is an ETS-regulated negative feedback mediator of oncogenic ERK signaling in lung cancer cells. Zhang Z, et al. Carcinogenesis, 2010 Apr. PMID 20097731. Down-regulation of DUSP6 expression in lung cancer: its mechanism and potential role in carcinogenesis. Okudela K, et al. Am J Pathol, 2009 Aug. PMID 19608870. Case-control association study of 65 candidate genes revealed a possible association of a SNP of HTR5A to be a factor susceptible to bipolar disease in Bulgarian population. Yosifova A, et al. J Affect Disord, 2009 Sep. PMID 19328558. Negative and positive regulation of MAPK phosphatase 3 controls platelet-derived growth factor-induced Erk activation. Jurek A, et al. J Biol Chem, 2009 Feb 13. PMID 19106095. Sphingosine-1-phosphate inhibits high glucose-mediated ERK1/2 action in endothelium through induction of MAP kinase phosphatase-3. Whetzel AM, et al. Am J Physiol Cell Physiol, 2009 Feb. PMID 19091959.
