EIF4EBP1 predesign siRNASynthetic RNA

BACKGROUND

This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation.

REFERENCES

4E-BP1 is a key effector of the oncogenic activation of the AKT and ERK signaling pathways that integrates their function in tumors. She QB, et al. Cancer Cell, 2010 Jul 13. PMID 20609351. Human cytomegalovirus UL69 protein facilitates translation by associating with the mRNA cap-binding complex and excluding 4EBP1. Aoyagi M, et al. Proc Natl Acad Sci U S A, 2010 Feb 9. PMID 20133758. The Parkinson's disease associated LRRK2 exhibits weaker in vitro phosphorylation of 4E-BP compared to autophosphorylation. Kumar A, et al. PLoS One, 2010 Jan 15. PMID 20090955. RhoE inhibits 4E-BP1 phosphorylation and eIF4E function impairing cap-dependent translation. Villalonga P, et al. J Biol Chem, 2009 Dec 18. PMID 19850923. 4E-BP1 is a target of Smad4 essential for TGFbeta-mediated inhibition of cell proliferation. Azar R, et al. EMBO J, 2009 Nov 18. PMID 19834456.