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FADD predesign siRNASynthetic RNA
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| RI11907 | 5 OD 400 ul | 13-15 days | $ 110.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
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FADD predesign siRNA - Additional info | |
| Gene ID | 8772 |
| Gene Symbol | FADD |
| Other Names GIG3, MORT1, MGC8528, FADD | |
| Format HPLC purified siRNA is supplied as a dried pellet in nmol quantities. | |
| Storage Maintain refrigerated at 2-8°C for up to one week. For long term storage store at -20°C. | |
| Precautions This product is for research use only. Not for use in diagnostic or therapeutic procedures. | |
FADD predesign siRNA - Related products
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BACKGROUND
The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development.
REFERENCES
Akt-phosphorylated mitogen-activated kinase-activating death domain protein (MADD) inhibits TRAIL-induced apoptosis by blocking Fas-associated death domain (FADD) association with death receptor 4. Li P, et al. J Biol Chem, 2010 Jul 16. PMID 20484047. Lack of Fas-pathway gene mutations in primary resected esophageal squamous cell carcinoma. Ko CL, et al. Chang Gung Med J, 2010 Mar-Apr. PMID 20438666. Protein kinase RNA/FADD/caspase-8 pathway mediates the proapoptotic activity of the RNA-binding protein human antigen R (HuR). von Roretz C, et al. J Biol Chem, 2010 May 28. PMID 20353946. Localization of the death effector domain of Fas-associated death domain protein into the membrane of Escherichia coli induces reactive oxygen species-involved cell death. Thorenoor N, et al. Biochemistry, 2010 Feb 23. PMID 20070122. Phosphorylation status of Fas-associated death domain-containing protein regulates telomerase activity and strongly correlates with prostate cancer outcomes. Matsumura Y, et al. Pathobiology, 2009. PMID 19955841.
