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GABARAP predesign siRNASynthetic RNA

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United States
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Ordering Information
Catalog # Size Availability Price  
RI12109 5 OD 400 ul 13-15 days $ 110.00 Add to cart
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GABARAP predesign siRNA - Additional info

Gene ID11337
Gene SymbolGABARAP
Other Names
MM46, FLJ25768, MGC120154, MGC120155, GABARAP
Format
HPLC purified siRNA is supplied as a dried pellet in nmol quantities.
Storage
Maintain refrigerated at 2-8°C for up to one week. For long term storage store at -20°C.
Precautions
This product is for research use only. Not for use in diagnostic or therapeutic procedures.

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Provided below are standard protocols that you may find useful for product applications.

BACKGROUND

Gamma-aminobutyric acid A receptors [GABA(A) receptors] are ligand-gated chloride channels that mediate inhibitory neurotransmission. This gene encodes GABA(A) receptor-associated protein, which is highly positively charged in its N-terminus and shares sequence similarity with light chain-3 of microtubule-associated proteins 1A and 1B. This protein clusters neurotransmitter receptors by mediating interaction with the cytoskeleton.

REFERENCES

Comparative modeling of human NSF reveals a possible binding mode of GABARAP and GATE-16. Thielmann Y, et al. Proteins, 2009 Nov 15. PMID 19533740. Nix directly binds to GABARAP: a possible crosstalk between apoptosis and autophagy. Schwarten M, et al. Autophagy, 2009 Jul. PMID 19363302. A role for NBR1 in autophagosomal degradation of ubiquitinated substrates. Kirkin V, et al. Mol Cell, 2009 Feb 27. PMID 19250911. Structural framework of the GABARAP-calreticulin interface--implications for substrate binding to endoplasmic reticulum chaperones. Thielmann Y, et al. FEBS J, 2009 Feb. PMID 19154346. Ligand binding mode of GABAA receptor-associated protein. Weiergr?ber OH, et al. J Mol Biol, 2008 Sep 19. PMID 18638487.