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GZMM predesign siRNASynthetic RNA
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| RI12387 | 5 OD 400 ul | 13-15 days | $ 110.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
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GZMM predesign siRNA - Additional info | |
| Gene ID | 3004 |
| Gene Symbol | GZMM |
| Other Names MET1, LMET1, GZMM | |
| Format HPLC purified siRNA is supplied as a dried pellet in nmol quantities. | |
| Storage Maintain refrigerated at 2-8°C for up to one week. For long term storage store at -20°C. | |
| Precautions This product is for research use only. Not for use in diagnostic or therapeutic procedures. | |
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Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Human natural killer (NK) cells and activated lymphocytes express and store a distinct subset of neutral serine proteases together with proteoglycans and other immune effector molecules in large cytoplasmic granules. These serine proteases are collectively termed granzymes and include 4 distinct gene products: granzyme A, granzyme B, granzyme H, and Met-ase, also known as granzyme M.
REFERENCES
Cleavage of survivin by Granzyme M triggers degradation of the survivin-X-linked inhibitor of apoptosis protein (XIAP) complex to free caspase activity leading to cytolysis of target tumor cells. Hu D, et al. J Biol Chem, 2010 Jun 11. PMID 20406824. The cytotoxic protease granzyme M is expressed by lymphocytes of both the innate and adaptive immune system. de Koning PJ, et al. Mol Immunol, 2010 Jan. PMID 19896187. Structural basis for proteolytic specificity of the human apoptosis-inducing granzyme M. Wu L, et al. J Immunol, 2009 Jul 1. PMID 19542453. Nucleophosmin is cleaved and inactivated by the cytotoxic granule protease granzyme M during natural killer cell-mediated killing. Cullen SP, et al. J Biol Chem, 2009 Feb 20. PMID 19103589. NK cell protease granzyme M targets alpha-tubulin and disorganizes the microtubule network. Bovenschen N, et al. J Immunol, 2008 Jun 15. PMID 18523284.
