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MAGEL2 predesign siRNASynthetic RNA
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| RI13140 | 5 OD 400 ul | 13-15 days | $ 110.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
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MAGEL2 predesign siRNA - Additional info | |
| Gene ID | 54551 |
| Gene Symbol | MAGEL2 |
| Other Names nM15, NDNL1, MAGEL2 | |
| Format HPLC purified siRNA is supplied as a dried pellet in nmol quantities. | |
| Storage Maintain refrigerated at 2-8°C for up to one week. For long term storage store at -20°C. | |
| Precautions This product is for research use only. Not for use in diagnostic or therapeutic procedures. | |
MAGEL2 predesign siRNA - Related products
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BACKGROUND
Prader-Willi syndrome (PWS) is caused by the loss of expression of imprinted genes in chromosome 15q11-q13. Affected individuals exhibit neonatal hypotonia, developmental delay, and childhood-onset obesity. Necdin (NDN), a gene involved in the terminal differentiation of neurons, localizes to this region of the genome and has been implicated as one of the genes responsible for the etiology of PWS. This gene is structurally similar to NDN, is also localized to the PWS chromosomal region, and is paternally imprinted, suggesting a possible role for it in PWS.
REFERENCES
Lack of Association Between MAGEL2 and Schizophrenia and Mood Disorders in the Japanese Population. Fukuo Y, et al. Neuromolecular Med, 2010 Sep. PMID 20467835. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932. Expression and imprinting of MAGEL2 suggest a role in Prader-willi syndrome and the homologous murine imprinting phenotype. Lee S, et al. Hum Mol Genet, 2000 Jul 22. PMID 10915770. The human MAGEL2 gene and its mouse homologue are paternally expressed and mapped to the Prader-Willi region. Boccaccio I, et al. Hum Mol Genet, 1999 Dec. PMID 10556298.
