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MAP3K12 predesign siRNASynthetic RNA
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| RI13164 | 5 OD 400 ul | 13-15 days | $ 110.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
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- Backgrounds
MAP3K12 predesign siRNA - Additional info | |
| Gene ID | 7786 |
| Gene Symbol | MAP3K12 |
| Other Names DLK, MUK, ZPK, ZPKP1, MEKK12, MAP3K12 | |
| Format HPLC purified siRNA is supplied as a dried pellet in nmol quantities. | |
| Storage Maintain refrigerated at 2-8°C for up to one week. For long term storage store at -20°C. | |
| Precautions This product is for research use only. Not for use in diagnostic or therapeutic procedures. | |
MAP3K12 predesign siRNA - Related products
AP7214a: ZPK Antibody (C-term)
AP7811a: ZPK Antibody (Center)
RI13164: MAP3K12 predesign siRNA
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BACKGROUND
This gene encodes a member of the serine/threonine protein kinase family. This kinase contains a leucine-zipper domain and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated by membrane depolarization via calcineurin. This kinase forms heterodimers with leucine zipper containing transcription factors, such as cAMP responsive element binding protein (CREB) and MYC, and thus may play a regulatory role in PKA or retinoic acid induced neuronal differentiation. Alternatively spliced transcript variants encoding different proteins have been described.
REFERENCES
Genetic variation in MicroRNA genes and risk of oral premalignant lesions. Clague J, et al. Mol Carcinog, 2010 Feb. PMID 19851984. The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors. Landa I, et al. PLoS Genet, 2009 Sep. PMID 19730683. The small heat-shock protein Hsp27 undergoes ERK-dependent phosphorylation and redistribution to the cytoskeleton in response to dual leucine zipper-bearing kinase expression. Robitaille H, et al. J Invest Dermatol, 2010 Jan. PMID 19675578. The mixed-lineage kinase DLK undergoes Src-dependent tyrosine phosphorylation and activation in cells exposed to vanadate or platelet-derived growth factor (PDGF). Daviau A, et al. Cell Signal, 2009 Apr. PMID 19146952. DAPK-ZIPK-L13a axis constitutes a negative-feedback module regulating inflammatory gene expression. Mukhopadhyay R, et al. Mol Cell, 2008 Nov 7. PMID 18995835.
