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MAPKSP1 predesign siRNASynthetic RNA
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| RI13203 | 5 OD 400 ul | 13-15 days | $ 110.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
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MAPKSP1 predesign siRNA - Additional info | |
| Gene ID | 8649 |
| Gene Symbol | MAPKSP1 |
| Other Names MP1, MAPBP, MAP2K1IP1, MAPKSP1 | |
| Format HPLC purified siRNA is supplied as a dried pellet in nmol quantities. | |
| Storage Maintain refrigerated at 2-8°C for up to one week. For long term storage store at -20°C. | |
| Precautions This product is for research use only. Not for use in diagnostic or therapeutic procedures. | |
MAPKSP1 predesign siRNA - Related products
RI13203: MAPKSP1 predesign siRNA
LY10172a: MAP2K1 Over-expression Lysate
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BACKGROUND
This gene encodes a scaffold protein that functions in the extracellular signal-regulated kinase (ERK) cascade. The protein is localized to late endosomes by the mitogen-activated protein-binding protein-interacting protein, and binds specifically to MAP kinase kinase MAP2K1/MEK1, MAP kinase MAPK3/ERK1, and MAP kinase MAPK1/ERK2. Studies of the orthologous gene in mouse indicate that it regulates late endosomal traffic and cell proliferation. Multiple transcript variants are expressed by this gene, but only one variant is thought to express a protein.
REFERENCES
Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids. Sancak Y, et al. Cell, 2010 Apr 16. PMID 20381137. RACK1 targets the extracellular signal-regulated kinase/mitogen-activated protein kinase pathway to link integrin engagement with focal adhesion disassembly and cell motility. Vomastek T, et al. Mol Cell Biol, 2007 Dec. PMID 17908799. Regulation of protein phosphorylation within the MKK1-ERK2 complex by MP1 and the MP1*P14 heterodimer. Brahma A, et al. Arch Biochem Biophys, 2007 Apr 1. PMID 17254543. p14-MP1-MEK1 signaling regulates endosomal traffic and cellular proliferation during tissue homeostasis. Teis D, et al. J Cell Biol, 2006 Dec 18. PMID 17178906. Glial-derived neurotrophic factor (GDNF) prevents ethanol (EtOH) induced B92 glial cell death by both PI3K/AKT and MEK/ERK signaling pathways. Villegas SN, et al. Brain Res Bull, 2006 Dec 11. PMID 17113937.
