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NAE1 predesign siRNASynthetic RNA
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| RI13484 | 5 OD 400 ul | 13-15 days | $ 110.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
- Protocols
- Backgrounds
NAE1 predesign siRNA - Additional info | |
| Gene ID | 8883 |
| Gene Symbol | NAE1 |
| Other Names HPP1, ula-1, APPBP1, A-116A10.1, NAE1 | |
| Format HPLC purified siRNA is supplied as a dried pellet in nmol quantities. | |
| Storage Maintain refrigerated at 2-8°C for up to one week. For long term storage store at -20°C. | |
| Precautions This product is for research use only. Not for use in diagnostic or therapeutic procedures. | |
NAE1 predesign siRNA - Related products
AP13067c: NAE1 Antibody (Center)
AP7273b: NAE1 (APPBP1) Antibody (C-term)
AP7273c: APPBP1 Antibody (Center)
AP7273d: APPBP1 Antibody (N-term)
AP7273e: NAE1 (APPBP1) Antibody (C-term)
DC00225: Human NAE1 cDNA Clone
LY11057a: NAE1 Over-expression Lysate
BP7273b: APPBP1 Antibody (C-term) Blocking Peptide
BP7273c: APPBP1 Antibody (Center) Blocking Peptide
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BACKGROUND
The protein encoded by this gene binds to the beta-amyloid precursor protein. Beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. In addition, the encoded protein can form a heterodimer with UBE1C and bind and activate NEDD8, a ubiquitin-like protein. This protein is required for cell cycle progression through the S/M checkpoint. Three transcript variants encoding different isoforms have been found for this gene.
REFERENCES
Biological and clinical relevance of transcriptionally active human papillomavirus (HPV) infection in oropharynx squamous cell carcinoma. Jung AC, et al. Int J Cancer, 2010 Apr 15. PMID 19795456. Defining the human deubiquitinating enzyme interaction landscape. Sowa ME, et al. Cell, 2009 Jul 23. PMID 19615732. TRIP12 functions as an E3 ubiquitin ligase of APP-BP1. Park Y, et al. Biochem Biophys Res Commun, 2008 Sep 19. PMID 18627766. Large-scale mapping of human protein-protein interactions by mass spectrometry. Ewing RM, et al. Mol Syst Biol, 2007. PMID 17353931. A general approach for investigating enzymatic pathways and substrates for ubiquitin-like modifiers. Li T, et al. Arch Biochem Biophys, 2006 Sep 1. PMID 16620772.
