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SAE1 predesign siRNASynthetic RNA

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Ordering Information
Catalog # Size Availability Price  
RI14696 5 OD 400 ul 13-15 days $ 110.00 Add to cart
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SAE1 predesign siRNA - Additional info

Gene ID10055
Gene SymbolSAE1
Other Names
AOS1, SUA1, UBLE1A, FLJ3091, HSPC140, SAE1
Format
HPLC purified siRNA is supplied as a dried pellet in nmol quantities.
Storage
Maintain refrigerated at 2-8°C for up to one week. For long term storage store at -20°C.
Precautions
This product is for research use only. Not for use in diagnostic or therapeutic procedures.

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Provided below are standard protocols that you may find useful for product applications.

BACKGROUND

Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 and UBA2 (MIM 613295) form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins (Okuma et al., 1999 [PubMed 9920803]).

REFERENCES

Large-scale mapping of human protein-protein interactions by mass spectrometry. Ewing RM, et al. Mol Syst Biol, 2007. PMID 17353931. A general approach for investigating enzymatic pathways and substrates for ubiquitin-like modifiers. Li T, et al. Arch Biochem Biophys, 2006 Sep 1. PMID 16620772. SUMO-1 controls the protein stability and the biological function of phosducin. Klenk C, et al. J Biol Chem, 2006 Mar 31. PMID 16421094. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560. Towards a proteome-scale map of the human protein-protein interaction network. Rual JF, et al. Nature, 2005 Oct 20. PMID 16189514.