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SLBP predesign siRNASynthetic RNA
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| RI14893 | 5 OD 400 ul | 13-15 days | $ 110.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
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- Backgrounds
SLBP predesign siRNA - Additional info | |
| Gene ID | 7884 |
| Gene Symbol | SLBP |
| Other Names HBP, SLBP | |
| Format HPLC purified siRNA is supplied as a dried pellet in nmol quantities. | |
| Storage Maintain refrigerated at 2-8°C for up to one week. For long term storage store at -20°C. | |
| Precautions This product is for research use only. Not for use in diagnostic or therapeutic procedures. | |
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BACKGROUND
This gene encodes a protein that binds to the stem-loop structure in replication-dependent histone mRNAs. Histone mRNAs do not contain introns or polyadenylation signals, and are processed by endonucleolytic cleavage. The stem-loop structure is essential for efficient processing but this structure also controls the transport, translation and stability of histone mRNAs. Expression of the protein is regulated during the cell cycle, increasing more than 10-fold during the latter part of G1.
REFERENCES
Knockdown of SLBP results in nuclear retention of histone mRNA. Sullivan KD, et al. RNA, 2009 Mar. PMID 19155325. Phosphorylation of threonine 61 by cyclin a/Cdk1 triggers degradation of stem-loop binding protein at the end of S phase. Koseoglu MM, et al. Mol Cell Biol, 2008 Jul. PMID 18490441. Degradation of histone mRNA requires oligouridylation followed by decapping and simultaneous degradation of the mRNA both 5' to 3' and 3' to 5'. Mullen TE, et al. Genes Dev, 2008 Jan 1. PMID 18172165. SLIP1, a factor required for activation of histone mRNA translation by the stem-loop binding protein. Cakmakci NG, et al. Mol Cell Biol, 2008 Feb. PMID 18025107. NELF interacts with CBC and participates in 3' end processing of replication-dependent histone mRNAs. Narita T, et al. Mol Cell, 2007 May 11. PMID 17499042.
