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BNIP3L BH3 Domain Peptide
Synthetic Peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9Z2F7 |
|---|---|
| Other Accession | O60238 |
| Sequence | GEKEVEALKKSADWVSDWSSR |
| Gene ID | 12177 |
|---|---|
| Other Names | BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like, NIP3-like protein X, NIP3L, Bnip3l, Nix |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | Bnip3l |
|---|---|
| Synonyms | Nix |
| Function | Induces apoptosis. Interacts with viral and cellular anti- apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix (By similarity). May function as a tumor suppressor (By similarity). |
| Cellular Location | Nucleus envelope. Endoplasmic reticulum. Mitochondrion outer membrane Membrane; Single-pass membrane protein Note=Colocalizes with SPATA18 at the mitochondrion outer membrane |
Research Areas
Citations (0)
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Application Protocols
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$ 277.78
Cat# SP1014a
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