- CITATIONS: 1
|Other Accession||Q9BXH1, Q99ML1|
|Calculated MW||2476.75 Da|
|Other Names||Bcl-2-binding component 3, p53 up-regulated modulator of apoptosis, Bbc3, Puma|
|Format||Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Puma BH3 Domain Peptide is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Essential mediator of p53/TP53-dependent and p53/TP53- independent apoptosis. Functions by promoting partial unfolding of BCL2L1 and dissociation of BCL2L1 from p53/TP53 (By similarity). Essential for ER stress-induced cell death (By similarity).|
|Cellular Location||Mitochondrion. Note=Localized to the mitochondria in order to induce cytochrome c release|
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