Dermaseptin
Synthetic Peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P24302 |
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Sequence | NH2-ALWKTMLKKLGTMALHAGKAALGAAADTISQGTQ-COOH |
Other Names | Dermaseptin-1, DS I, Dermaseptin-S1, DS1, DMS1 |
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Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | DRS1 |
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Function | Antimicrobial activity with potent activity against Gram- positive and Gram-negative bacteria, fungi and protozoa (PubMed:1909573, PubMed:8306981, PubMed:8294443). Also stimulates the microbicidal activity of polymorphonuclear leukocytes (PubMed:9647785). Probably acts by disturbing membrane functions with its amphipathic structure (PubMed:8306981). Does not show cytotoxicity on lymphocytes or KB cells (PubMed:8294443). Does not show hemolytic activity (PubMed:1909573, PubMed:8294443, PubMed:21262294). In vitro, shows spermicidal, antiviral, and anti-leishmanial activities (PubMed:16307969, PubMed:16140737, PubMed:21262294). |
Cellular Location | Secreted |
Tissue Location | Expressed by the skin glands. |
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