Foundational characteristics of cancer include proliferation, angiogenesis, migration, evasion of apoptosis, and cellular immortality. Find key markers for these cellular processes and antibodies to detect them.
The SUMOplot™ Analysis Program predicts and scores sumoylation sites in your protein. SUMOylation is a post-translational modification involved in various cellular processes, such as nuclear-cytosolic transport, transcriptional regulation, apoptosis, protein stability, response to stress, and progression through the cell cycle.
The Autophagy Receptor Motif Plotter predicts and scores autophagy receptor binding sites in your protein. Identifying proteins connected to this pathway is critical to understanding the role of autophagy in physiological as well as pathological processes such as development, differentiation, neurodegenerative diseases, stress, infection, and cancer.
Crabrolin
Synthetic Peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P01518 |
|---|---|
| Sequence | NH2-FLPLILRKIVTAL-CONH2 |
| Other Names | Crabrolin, CRBL |
|---|---|
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | CRBL |
|---|---|
| Function | Antimicrobial and mast cell degranulating peptide (PubMed:6206053, PubMed:9273892, PubMed:31487493). Shows low antimicrobial activity towards some Gram-negative bacteria (E.coli MIC=300 ug/ml, S.typhimurium MIC=300 ug/ml) and all Gram-positive bacteria tested (B.subtilis MIC=300 ug/ml, S.aureus MIC=300 ug/ml, E.faecalis MIC=150 ug/ml, and E.faecium MIC=75 ug/ml) (PubMed:9273892, PubMed:31487493). May act by permeabilizing membranes, since it permeabilizes liposomes composed by phosphatidylethanolamine(PE)/phosphatidylglycerol(PG) and cardiolipin(CL)/phosphatidylglycerol(PG), which mimic the membranes of Gram-negative and Gram-positive bacteria, respectively (PubMed:31487493). Causes hemolysis on rat and guinea pig erythrocytes (PubMed:6206053, PubMed:9273892). Its mast cell degranulation activity may be related to the activation of G-protein coupled receptors in mast cells as well as interaction with other proteins located in cell endosomal membranes in the mast cells (By similarity). |
| Cellular Location | Secreted. Target cell membrane. Note=Assumes an amphipathic alpha-helical conformation in a membrane-like environment |
| Tissue Location | Expressed by the venom gland. |
Research Areas
Citations (0)
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
Submit your citation using an Abcepta antibody to
info@abcepta.com, and receive a free "I Love Antibodies" mug.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Abcepta welcomes feedback from its customers.
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.
$ 277.78
Cat# SP2221b
Ordering Information
United States
AlbaniaAustraliaAustriaBelgiumBosnia & HerzegovinaBrazilBulgariaCanadaCentral AmericaChinaCroatiaCyprusCzech RepublicDenmarkEstoniaFinlandFranceGermanyGreeceHong KongHungaryIcelandIndiaIndonesiaIrelandIsraelItalyJapanLatviaLithuaniaLuxembourgMacedoniaMalaysiaMaltaNetherlandsNew ZealandNorwayPakistanPolandPortugalRomaniaSerbiaSingaporeSlovakiaSloveniaSouth AfricaSouth KoreaSpainSwedenSwitzerlandTaiwanTurkeyUnited KingdomUnited StatesVietnamWorldwideOthers
USA Headquarters
(888) 735-7227 / (858) 622-0099 or (858) 875-1900
Shipping Information
Domestic orders (in stock items)
Shipped out the same day. Orders placed after 1 PM (PST) will ship out the next business day.
International orders
Contact your local distributors
