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Drosocin
Synthetic Peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P36193 |
|---|---|
| Other Accession | Q6XMH8 |
| Sequence | NH2-GKPRPYSPRPTSHPRPIRV-COOH |
| Gene ID | 36635 |
|---|---|
| Other Names | Drosocin, Dro |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | Dro |
|---|---|
| Function | [Drosocin]: Antibacterial peptide with strong anti-Gram- negative bacteria activity (PubMed:8325867). Significantly contributes to antibacterial activity against Enterobacter cloacae but not Providencia burhodogranariea (PubMed:35730150). Inhibitor of bacterial translation machinery that targets translation termination in a prfA- or prfB-dependent manner (PubMed:36997646). Binds within the nascent peptide exit tunnel of the bacterial large ribosomal subunit, potentially interfering with nascent chain translocation that occurs post-peptide bond formation (PubMed:36997646, PubMed:36997647). Binds prfA/RF1 (and potentially prfB/RF2), trapping it on the ribosome after release of the nascent polypeptide chain and preventing further translation (PubMed:36997646). The resulting depletion of peptide chain release factors further disrupts bacterial translation by preventing ribosomal peptide chain release and inducing stop codon readthrough (PubMed:36997647). Entry into target Escherichia coli cells requires the bacterial peptide antibiotic transporter sbmA (PubMed:36997646). |
| Cellular Location | [Drosocin]: Secreted |
| Tissue Location | Constitutively expressed in the calyx and oviduct of the genital tract of fertilised egg-laying females, but not virgin females (PubMed:8944755). Not expressed in male genital tract (PubMed:8944755). Inducibly expressed in the fat body (PubMed:8944755) [Buletin]: Hemolymph (at protein level). |
Research Areas
Citations (0)
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
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$ 277.78
Cat# SP2242a
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