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E7 (43 - 62), HPV Oncoprotein
Synthetic Peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P03129 |
|---|---|
| Sequence | NH2-GQAEPDRAHYNIVTFCCKCD-COOH |
| Gene ID | 1489079 |
|---|---|
| Other Names | Protein E7, E7 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | E7 {ECO:0000255|HAMAP-Rule:MF_04004} |
|---|---|
| Function | Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. E7 protein has both transforming and trans-activating activities. Induces the disassembly of the E2F1 transcription factor from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Interferes with host histone deacetylation mediated by HDAC1 and HDAC2, leading to transcription activation. Also plays a role in the inhibition of both antiviral and antiproliferative functions of host interferon alpha. Interaction with host TMEM173/STING impairs the ability of TMEM173/STING to sense cytosolic DNA and promote the production of type I interferon (IFN-alpha and IFN-beta). |
| Cellular Location | Host cytoplasm {ECO:0000255|HAMAP-Rule:MF_04004, ECO:0000269|PubMed:18996550, ECO:0000269|PubMed:3033296}. Host nucleus {ECO:0000255|HAMAP-Rule:MF_04004, ECO:0000269|PubMed:18996550} Note=Predominantly found in the host nucleus. {ECO:0000255|HAMAP- Rule:MF_04004, ECO:0000269|PubMed:18996550} |
Research Areas
Citations (0)
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$ 277.78
Cat# SP2256b
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