|Calculated MW||2879.4 Da|
|Other Names||Phorbol-12-myristate-13-acetate-induced protein 1, Protein Noxa, Pmaip1, Noxa|
|Format||Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||NOXA BH3, Peptide 2 is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1 (By similarity). Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1.|
|Tissue Location||Detected in thymocytes after irradiation with X-rays. Not detectable in untreated thymocytes (at protein level) Detected in embryonic neural precursor cells of the telencephalon Constitutively expressed at low levels in adult brain, testis, thymus, spleen, lung and kidney.|
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