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Angiogenin Fragment (108-123)

Synthetic Peptide

Product Information
Primary Accession Q8WME8
Other Accession P03950, Q71MJ0
Peptide ID 9071504
Calculated MW 1878.11 Da
Additional Information
Gene ID 494026
Other Names Angiogenin, 3127-, Ribonuclease 5, RNase 5, ANG, RNASE5
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ANG
Synonyms RNASE5
Function Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA. Cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs) (By similarity). Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo (By similarity).
Cellular Location Nucleus {ECO:0000250|UniProtKB:P03950}. Secreted, extracellular space, extracellular matrix, basement membrane. Nucleus, nucleolus Note=Rapidly endocytosed by target cells and translocated to the nucleus where it accumulates in the nucleolus and binds to DNA
Research Areas
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Cat# SP2658b
(40 western blots)
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