Neuromedin U, rat
Synthetic Peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P12760 |
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Sequence | NH2-YKVNEYQGPVAPSGGFFLFRPRN-CONH2 |
Gene ID | 63887 |
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Other Names | Neuromedin-U, Neuromedin-U-23, NmU-23, Nmu |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | Nmu |
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Function | [Neuromedin-U-23]: Ligand for receptors NMUR1 and NMUR2 (PubMed:28874765). Receptor-binding is very tight if not irreversible and triggers an increase in the cytosolic Ca(2+) concentration (PubMed:28874765). Stimulates muscle contractions of specific regions of the gastrointestinal tract. In rat, NMU stimulates contractions of stomach circular muscle. |
Cellular Location | [Neuromedin-U-23]: Secreted |
Tissue Location | Expressed throughout the gastrointestinal tract with highest levels in the duodenum and jejunum (PubMed:7916966). Low levels in spinal cord, hypothalamus, and stomach (PubMed:7916966) Neuromedin-U-23: Expressed in the small intestine and the pituitary gland (at protein level) (PubMed:28874765). Neuromedin precursor- related peptides: Expressed in pituitary gland and small intestine (at protein level) (PubMed:28874765). |
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