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Background
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Apoptosis is a critical aspect of cellular function and is implicated in a broad range of human diseases, from cancer to neurodegenerative and cardiovascular diseases. Intrafamilial Bcl-2 protein contacts are thought to regulate key aspects of apoptosis. The corruption of apoptotic instructions is associated with a large subset of human diseases, ranging from cancer and cardiovascular disease to neurodegenerative diseases, and name just a few. Understanding regulation of apoptosis is necessary to constructing a strategy for pharmaceutical intervention. The BH3 domain of Bcl-2 family members has been identified as key to the Bcl-2 regulatory function, although details are not fully elucidated.
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Background
References
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- Chiang, C.W., et al., Mol. Cell. Biol. 23(18):6350-6362 (2003).
- Danial, N.N., et al., Nature 424(6951):952-956 (2003).
- Ranger, A.M., et al., Proc. Natl. Acad. Sci. U.S.A. 100(16):9324-9329 (2003).
- Benetti, L., et al., J. Virol. 77(11):6567-6573 (2003).
- Ibata-Ombetta, S., et al., J. Biol. Chem. 278(15):13086-13093 (2003).
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