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Background
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The Grb2-associated binder 1 (Gab1) is a multisubstrate scaffold/adapter protein that contains a pleckstrin homology domain at the NH2 terminus and multiple tyrosyl residues and proline-rich motifs for association with src homology 2 (SH2)-containing and SH3-containing proteins. Gab1, as well as its close relatives Gab2 and Gab3, serves to couple signaling between cell surface receptors for growth factors and cytokines with a variety of downstream targets, including Shp2 tyrosine phosphatase, phosphatidylinositol 3-kinase (PI3K), and phospholipase C-gamma. Ablation of the Gab1 gene in mice resulted in embryonic death in homozygous mutants, with developmental defects in the placenta, heart, and skin. Biochemical analysis of Gab1-/- fibroblast cells suggested a positive role of Gab1 in coupling the signal relay between cytokine receptors and the ERK pathway.
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Background
References
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- Podar, K., et al., J. Biol. Chem. 279(20):21658-21665 (2004).
- Ren, Y., et al., J. Biol. Chem. 279(9):8497-8505 (2004).
- Kapoor, G.S., et al., Mol. Cell. Biol. 24(2):823-836 (2004).
- Nakaoka, Y., et al., Circ. Res. 93(3):221-229 (2003).
- Holgado-Madruga, M., et al., Mol. Cell. Biol. 23(13):4471-4484 (2003).
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