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Background
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VGFR3 is a tyrosine kinase receptor for vascular endothelial growth factors C and D. This protein is thought to be involved in lymphangiogenesis and maintenance of the lymphatic endothelium. Mutations in the gene coding for this protein cause hereditary lymphedema type IA.
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Background
References
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- Walter, J.W., et al., Genes Chromosomes Cancer 33(3):295-303 (2002).
- Karkkainen, M.J., et al., Nat. Genet. 25(2):153-159 (2000).
- Irrthum, A., et al., Am. J. Hum. Genet. 67(2):295-301 (2000).
- Ferrell, R.E., et al., Hum. Mol. Genet. 7(13):2073-2078 (1998).
- Galland, F., et al., Oncogene 8(5):1233-1240 (1993).
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