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Background
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The gene for SRC is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. SRC, the protein encoded by this gene, is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in SRC could be involved in the malignant progression of colon cancer.
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Background
References
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- Lopez, R.G., et al., J. Biol. Chem. 278(42):41316-41325 (2003).
- Horn, S., et al., Oncogene 22(46):7170-7180 (2003).
- Hakam, A., et al., Dig. Dis. Sci. 48(10):1972-1978 (2003).
- Ito, H., et al., Surgery 134(2):221-226 (2003).
- Bouchard, M.J., et al., J. Virol. 77(14):7713-7719 (2003).
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