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Background
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FGFR4 is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis.
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Background
References
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- Jezequel, P., et al., Br. J. Cancer 90(1):189-193 (2004).
- Qian, Z.R., et al., J. Clin. Endocrinol. Metab. 89(4):1904-1911 (2004).
- Yu, S., et al., J. Biol. Chem. 278(22):19597-19602 (2003).
- Becker, N., et al., Cancer Epidemiol. Biomarkers Prev. 12(6):582-583 (2003).
- Takenaka, H., et al., Arch. Dermatol. Res. 294(7):331-338 (2002).
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