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Background
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IKK alpha is a member of the serine/threonine protein kinase family. The encoded protein, a component of a cytokine-activated protein complex that is an inhibitor of the essential transcription factor NF-kappa-B complex, phosphorylates sites that trigger the degradation of the inhibitor via the
ubiquination pathway, thereby activating the transcription factor.
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Background
References
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- Xiao, G., et al., J. Biol. Chem. 279(29):30099-30105 (2004).
- Krappmann, D., et al., Mol. Cell. Biol. 24(14):6488-6500 (2004).
- Hironaka, N., et al., Neoplasia 6(3):266-278 (2004).
- O'Mahony, A.M., et al., J. Biol. Chem. 279(18):18137-18145 (2004).
- Gustin, J.A., et al., J. Biol. Chem. 279(3):1615-1620 (2004).
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