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Background
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IKK beta is a member of the serine/threonine protein kinase family. The encoded protein, a component of a cytokine-activated protein complex that is an inhibitor of the essential transcription factor NF-kappa-B complex, phosphorylates sites that trigger the degradation of the inhibitor via the ubiquination pathway, thereby activating the transcription factor.
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Background
References
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- Carcamo, J.M., et al., Mol. Cell. Biol. 24(15):6645-6652 (2004).
- Xiao, G., et al., J. Biol. Chem. 279(29):30099-30105 (2004).
- Mattioli, I., et al., J. Immunol. 172(10):6336-6344 (2004).
- Viemann, D., et al., Blood 103(9):3365-3373 (2004).
- Caposio, P., et al., J. Virol. 78(6):3190-3195 (2004).
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