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Background
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Arginine methylation is an irreversible post translational modification which has only recently been linked to protein activity. At least three types of PRMT enzymes have been identified in mammalian cells. These enzymes have been shown to have essential regulatory functions by methylation of key proteins in several fundamental areas. These protein include nuclear proteins, IL enhancer binding factor, nuclear factors, cell cycle proteins, signal transduction proteins, apoptosis proteins, and viral proteins. The mammalian PRMT family currently consists of 7 members that share two large domains of homology. Outside of these domains, epitopes were identified and antibodies against all 7 PRMT members have been developed.
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Background
References
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- Zhang, X., et al., EMBO J. 19(14):3509-3519 (2000).
- Scorilas, A., et al., Biochem. Biophys. Res. Commun. 278(2):349-359 (2000).
- Scott, H.S., et al., Genomics 48(3):330-340 (1998).
- Abramovich, C., et al., EMBO J. 16(2):260-266 (1997).
- Nikawa, J., et al., Gene 171(1):107-111 (1996).
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