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Background
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EHMT1, also known as EUHMTASE1, is a histone methyltransferase. This protein methylates 'Lys-9' of histone H3 in vitro. H3 'Lys-9' methylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. EHMT1 is Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. During G0 phase, it probably contributes to silencing of MYC- and E2F-responsive genes, suggesting a role in the G0/G1 transition of the cell cycle.
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Background
References
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- Ogawa H.,Science 296:1132-1136(2002).
- Ota T.,Nat. Genet. 36:40-45(2004).
- Nagase T.,DNA Res. 8:85-95(2001).
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List Price (USA): $235.00/0.1mg
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