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Background
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CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. Dnmt3a is a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated.
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Background
References
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- Xie, S., et al., Gene 236(1):87-95 (1999).
- Robertson, K.D., et al., Nucleic Acids Res. 27(11):2291-2298 (1999).
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