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Background
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The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme associates with AppBp1, an amyloid beta precursor protein binding protein, to form a heterodimer, and then the enzyme complex activates NEDD8, a ubiquitin-like protein, which regulates cell division, signaling and embryogenesis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
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Background
References
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- Bohnsack, R.N., et al., J. Biol. Chem. 278(29):26823-26830 (2003).
- Walden, H., et al., Nature 422(6929):330-334 (2003).
- Gong, L., et al., J. Biol. Chem. 274(17):12036-12042 (1999).
- Gubin, A.N., et al., Genomics 59(2):168-177 (1999).
- Osaka, F., et al., Genes Dev. 12(15):2263-2268 (1998).
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