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Background
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The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is linked with a ubiquitin-like protein, NEDD8, which can be conjugated to cellular proteins, such as Cdc53/culin.
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Background
References
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- Gong, L., et al., J. Biol. Chem. 274(17):12036-12042 (1999).
- Osaka, F., et al., Genes Dev. 12(15):2263-2268 (1998).
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List Price (USA): $235.00/0.1mg
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