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Background
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The SET domain is a highly conserved, approximately 150-amino acid motif implicated in the modulation of chromatin structure. It was originally identified as part of a larger conserved region present in the Drosophila Trithorax protein and was subsequently identified in the Drosophila Su(var)3-9 and 'Enhancer of zeste' proteins, from which the acronym SET is derived. Studies have suggested that the SET domain may be a signature of proteins that modulate transcriptionally active or repressed chromatin states through chromatin remodeling activities.
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Background
References
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- Ichimura, T., et al., J. Biol. Chem. 280(14):13928-13935 (2005).
- Sarraf, S.A., et al., Mol. Cell 15(4):595-605 (2004).
- Wang, H., et al., Mol. Cell 12(2):475-487 (2003).
- Schultz, D.C., et al., Genes Dev. 16(8):919-932 (2002).
- Yang, L., et al., Biochem. J. 369 (PT 3), 651-657 (2003) (): ().
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