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Background
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Proteins that contain a SET domain, such as SETDB2, modulate gene expression epigenetically through histone H3 methylation. SETDB2 is likely a histone H3 methyltransferase, as it contains both the active site and flanking cysteine residues required for catalytic activity.
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Background
References
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- Zhang, Y., et al., Nat. Genet. 34(2):181-186 (2003).
- Mabuchi, H., et al., Cancer Res. 61(7):2870-2877 (2001).
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