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Background
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GCN5L2 functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Acetylation of histones gives a specific tag for epigenetic transcription activation. This protein has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles
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Background
References
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- Kikuchi, H., et al., Gene 347(1):83-97 (2005).
- Gangisetty, O., et al., Oncogene 23(14):2559-2563 (2004).
- Lusic, M., et al., EMBO J. 22(24):6550-6561 (2003).
- Fulco, M., et al., Mol. Cell 12(1):51-62 (2003).
- Liu, X., et al., J. Biol. Chem. 278(22):20405-20412 (2003).
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