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Background
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GCN5 functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Acetylation of histones gives a specific tag for epigenetic transcription activation. This protein has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles.
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Background
References
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- Sabo,A., Mol. Cell. Biol. 28 (7), 2201-2212 (2008)
- Wiper-Bergeron,N., Proc. Natl. Acad. Sci. U.S.A. 104 (8), 2703-2708 (2007)
- Oishi,H., J. Biol. Chem. 281 (1), 20-26 (2006)
- Kikuchi,H., Gene 347 (1), 83-97 (2005)
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