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Background
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Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. HDAC1 belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis.
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Background
References
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- Di Padova, M., et al., J. Biol. Chem. 278(38):36496-36504 (2003).
- Wang, S., et al., Oncogene 22(40):6204-6213 (2003).
- Xia, Z.B., et al., Proc. Natl. Acad. Sci. U.S.A. 100(14):8342-8347 (2003).
- Rocha, S., et al., Mol. Cell. Biol. 23(13):4713-4727 (2003).
- Macaluso, M., et al., Oncogene 22(23):3511-3517 (2003).
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