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Background
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Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. HDAC1 belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis.
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Background
References
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- Meinke PT and Liberator P. Curr Med Chem, 8(2): 211- 235 (2001).
- Nakayama T and Takami Y. J Biochem (Tokyo) 129 (4): 491-499 (2001).
- Cress, W.D. and Seto, E. J. Cell. Physiol. 184, 1-16 (2000).
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