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Background
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Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. HDAC3 belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. HDAC3 is
regarded as a potential tumor suppressor gene.
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Background
References
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- Ishizuka, T., et al., Mol. Cell. Biol. 23(15):5122-5131 (2003).
- Weiss, C., et al., EMBO J. 22(14):3686-3695 (2003).
- Murphy, J.C., et al., EMBO J. 21(5):1112-1120 (2002).
- Zhang, J., et al., Mol. Cell 9(3):611-623 (2002).
- Juan, L.J., et al., J. Biol. Chem. 275(27):20436-20443 (2000).
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