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Background
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Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been noted for this gene.
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Background
References
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- Berger, I., et al., J. Biol. Chem. 278(20):17625-17635 (2003).
- Zhang, C.L., et al., Mol. Cell. Biol. 22(20):7302-7312 (2002).
- Lemercier, C., et al., J. Biol. Chem. 277(24):22045-22052 (2002).
- Huang, Y., et al., Cancer Res. 62(10):2913-2922 (2002).
- Grozinger, C.M., et al., Proc. Natl. Acad. Sci. U.S.A. 97(14):7835-7840 (2000).
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