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Background
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NCOR1 mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. The gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. An alternatively spliced transcript variant has been described, but its full length sequence has not been determined.
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Background
References
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- Tai, H.H., et al., Biochem. Biophys. Res. Commun. 308(1):170-176 (2003).
- Ishizuka, T., et al., Mol. Cell. Biol. 23(15):5122-5131 (2003).
- Loinder, K., et al., J. Steroid Biochem. Mol. Biol. 84(1):15-21 (2003).
- Wang, S., et al., Oncogene 21(55):8388-8396 (2002).
- Baek, S.H., et al., Cell 110(1):55-67 (2002).
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