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Background
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SUSP1 (SENP6) is a protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. This protein does not seem to be involved in the processing of full-length SUMO proteins to their mature conjugatable forms. SUSP1 deconjugates SUMO1 from RXRA, leading to transcriptional activation. It may act preferentially on substrates containing 3 or more SUMO2 or SUMO3 moieties.
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Background
References
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- Bailey, D., et al., J. Biol. Chem. 279(1):692-703 (2004).
- Kim, K.I., et al., J. Biol. Chem. 275(19):14102-14106 (2000).
- Yeh, E.T., et al., Gene 248 (1-2), 1-14 (2000).
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