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Background
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This gene encodes a protein that acts as a repressor of beta-interferon gene expression. The protein binds specifically to the PRDI (positive regulatory domain I element) of the beta-IFN gene promoter. Transcription of this gene increases upon virus induction. Two alternatively spliced transcript variants that encode different isoforms have been reported. The protein encoded by this transcript has also been named PRDI-BF1alpha.
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Background
References
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- Gyory, I., et al., J. Immunol. 170(6):3125-3133 (2003).
- Borson, N.D., et al., Blood 100(13):4629-4639 (2002).
- Vasanwala, F.H., et al., J. Immunol. 169(4):1922-1929 (2002).
- Shaffer, A.L., et al., Immunity 17(1):51-62 (2002).
- Medina, F., et al., Blood 99(6):2154-2161 (2002).
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