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Background
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PRDM2 is a 250-kD nuclear protein containing 8 zinc finger motifs. It contains an RB-binding motif that is related to that of the adenovirus E1A oncoprotein; RIZ also shares an antigenic epitope with the C terminus of E1A. It is expressed in human retinoblastoma cells and at low levels in all other human cell lines examined. Using fluorescence in situ hybridization, the PRDM2 gene has been mapped to 1p36. PRDM2 may be a candidate target of 1p36 alterations that commonly occur in neuroendocrine, breast, liver, colon, skin, and lymphoid tumors.
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Background
References
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- Muraosa, Y., et al., Eur. J. Biochem. 235(3):471-479 (1996).
- Buyse, I.M., et al., Proc. Natl. Acad. Sci. U.S.A. 92(10):4467-4471 (1995).
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