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Background
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PIAS1 functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. This protein plays a crucial role in transcriptional coregulation of various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. It functions in testis as a nuclear receptor transcriptional coregulator and may have a role in androgen receptor initiation and maintenance of spermatogenesis. The effects of transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context.
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Background
References
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- Miyauchi, Y., et al., J. Biol. Chem. 277(51):50131-50136 (2002).
- Nishida, T., et al., J. Biol. Chem. 277(44):41311-41317 (2002).
- Tan, J.A., et al., J. Biol. Chem. 277(19):16993-17001 (2002).
- Megidish, T., et al., J. Biol. Chem. 277(10):8255-8259 (2002).
- Liu, B., et al., J. Biol. Chem. 276(39):36624-36631 (2001).
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