|
Background
|
NEDD8 is a ubiquitin-like protein that becomes conjugated to the cullin subunit of several ubiquitin ligases. This conjugation, called neddylation, is required for optimal ubiquitin ligase activity. SENP8 is a protease that catalyzes two essential functions in the NEDD8 pathway: processing of full-length NEDD8 to its mature form and deconjugation of NEDD8 from targeted proteins such as cullins or p53.
|
Background
References
|
- Wu, K., et al., J. Biol. Chem. 278(31):28882-28891 (2003).
- Gan-Erdene, T., et al., J. Biol. Chem. 278(31):28892-28900 (2003).
- Mendoza, H.M., et al., J. Biol. Chem. 278(28):25637-25643 (2003).
|
Order Information
List Price (USA): $235.00/0.1mg
Related Products
Data Rewards Program
