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Background
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Human Ubquitin Conjugating Enzyme 9 (Ubc9) is a member of the E2 family and is specific for the conjugation of SUMO to a variety of target proteins. SUMO conjugation to target proteins is mediated by a different, but analogous, pathway to ubiquitinylation. This E2 is unusual in that it interacts directly with protein substrates that are modified by sumoylation, and may play a role in substrate recognition. Ubc9 can mediate the conjugation of SUMO-1 to a variety of proteins including RanGAP1, IκBα, and PML without the requirement of an E3 ligase. Ubc9 is essential for nuclear architecture and chromosome segregation.
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Background
References
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- Weldon, R.A. Jr., et al., Virology 314(1):62-73 (2003).
- Lin, X., et al., J. Biol. Chem. 278(33):31043-31048 (2003).
- Netzer, C., et al., Biochem. Biophys. Res. Commun. 296(4):870-876 (2002).
- Sheng, W., et al., Protein Sci. 11(6):1482-1491 (2002).
- Lin, D., et al., J. Biol. Chem. 277(24):21740-21748 (2002).
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