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Background
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The dimeric enzyme AOS1 acts as a an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins and formation of a thioester with a conserved cysteine residue on SAE2.
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Background
References
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- Desterro, J.M., et al., J. Biol. Chem. 274(15):10618-10624 (1999).
- Gong, L., et al., FEBS Lett. 448(1):185-189 (1999).
- Okuma, T., et al., Biochem. Biophys. Res. Commun. 254(3):693-698 (1999).
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