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Background
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Bcl-2 related Protein A1 is a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities such as embryonic development, homeostasis and tumorigenesis. The protein encoded by this gene is able to reduce the release of pro-apoptotic cytochrome c from mitochondria and block caspase activation. This gene is a direct transcription target of NF-kappa B in response to inflammatory mediators, and has been shown to be up-regulated by different extracellular signals, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), CD40, phorbol ester and inflammatory cytokine TNF and IL-1, which suggests a cytoprotective function that is essential for lymphocyte activation as well as cell survival.
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Background
References
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- Akatsuka, Y., et al., J. Exp. Med. 197(11):1489-1500 (2003).
- Edelstein, L.C., et al., Mol. Cell. Biol. 23(8):2749-2761 (2003).
- Werner, A.B., et al., J. Biol. Chem. 277(25):22781-22788 (2002).
- Akari, H., et al., J. Exp. Med. 194(9):1299-1311 (2001).
- Harrington, J.J., et al., Nat. Biotechnol. 19(5):440-445 (2001).
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